In which patients is kidney transplantation contraindicated?

In the context of kidney transplantation, certain medical conditions and patient characteristics can significantly influence the eligibility for the procedure. The selected answer points to a situation involving a patient diagnosed with non-Hodgkin lymphoma who is actively undergoing chemotherapy and has a history of multiple coronary bypass graft surgeries.

Chemotherapy can compromise the immune system, posing a risk for significant complications following transplantation. An active malignancy, such as non-Hodgkin lymphoma, is considered a contraindication because it suggests ongoing disease that could not only threaten the patient's overall health but also result in lower survival rates post-transplant. The body’s ability to tolerate immunosuppressive medications, which are crucial to prevent organ rejection, is also compromised in these patients due to their present oncological condition.

Additionally, the history of multiple coronary bypass surgeries raises concerns about the patient’s cardiovascular health. Cardiovascular disease is a leading cause of morbidity and mortality in transplant recipients, and patients with significant comorbidities may face higher risks during and after the transplant process.

In contrast, the other scenarios presented involve either patients with manageable conditions or those who, despite comorbidities, are actively working with their healthcare team to manage their health status. For instance, a body mass index of 35 and