What are some disadvantages of using hollow-fiber dialyzers?

Choosing the answer that highlights the uneven blood distribution at the inflow header space captures a significant disadvantage of hollow-fiber dialyzers. The design of these dialyzers can lead to challenges in achieving uniform blood flow through the fibers. This uneven distribution can compromise the efficiency of the dialysis process, leading to areas where blood is not adequately cleared of toxins or excess fluid. Consequently, this can negatively impact patient outcomes, as the effectiveness of treatment may be diminished.

The other concerns associated with hollow-fiber dialyzers do play important roles in their overall management and use. For instance, meticulous care to remove air from the fiber bundle is crucial to prevent complications like air embolism, and the need for adjustment in heparin dosing is significant due to higher risks of clotting in the fibers. However, the principal issue of uneven blood distribution stands out as a fundamental disadvantage that can affect the overall efficacy of hemodialysis treatment.